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ClinicalOncologyNSCLCTrial Update

Merck and Gilead Discontinue Phase 3 Study of Trodelvy and KEYTRUDA in NSCLC

The discontinuation of the Phase 3 study for Trodelvy and KEYTRUDA in NSCLC is a significant setback for both Merck and Gilead, impacting their competitive positioning in the oncology market. This event necessitates a reevaluation of their strategies and potential partnerships in this therapeutic area.

Published: June 16, 2026
Updated: June 16, 2026
Author: Humanexa Intelligence
Therapeutic area: Oncology / NSCLC
Company: Merck
Asset: Trodelvy
Trial SummaryCLN

Phase III

Oncology / NSCLC

Status

Positive

Sponsor

Merck

Signal Score

8.4

Signal assessment

Signal strength

high

Confidence level

high

Signalhigh
Confidencehigh

Strategic implication

The discontinuation of the Phase 3 study for Trodelvy and KEYTRUDA in NSCLC is a significant setback for both Merck and Gilead, impacting their competitive positioning in the oncology market. This event necessitates a reevaluation of their strategies and potential partnerships in this therapeutic area.

Why it matters

The discontinuation of the Phase 3 study for Trodelvy and KEYTRUDA in NSCLC is a significant setback for both Merck and Gilead, impacting their competitive positioning in the oncology market. This event necessitates a reevaluation of their strategies and potential partnerships in this therapeutic area.

What changed

Trial Update

Analysis

The Phase 3 KEYNOTE-D46/EVOKE-03 study of Trodelvy and KEYTRUDA has been discontinued due to lack of statistically significant efficacy.

The discontinuation of the Phase 3 study for Trodelvy and KEYTRUDA in NSCLC is a significant setback for both Merck and Gilead, impacting their competitive positioning in the oncology market. This event necessitates a reevaluation of their strategies and potential partnerships in this therapeutic area.

Monitor for further data releases from the study and any strategic shifts from Merck or Gilead regarding their NSCLC portfolios.

Related companies & assets

Companies

  • View signals for Merck →
  • View signals for non-small cell lung cancer →
  • View signals for Oncology →

Assets

  • Trodelvy →

Sources & Humanexa intelligence

Source links

  • Merck and Gilead Provide Update on Phase 3 KEYNOTE-D46/EVOKE-03 Study ↗
  • Merck and Gilead Discontinue Phase 3 Study of Trodelvy and KEYTRUDA in NSCLC ↗

Related Humanexa pages

  • Merck and Gilead Discontinue Phase 3 Study of Trodelvy and KEYTRUDA in NSCLC →

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