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ClinicalOncologyColorectal CancerTrial Update

Cardiff Oncology and Pfizer assess onvansertib in metastatic colorectal cancer trial

The ongoing trial of onvansertib in combination with standard therapies for metastatic colorectal cancer could significantly impact treatment options for patients with specific mutations. Success in this trial may enhance Cardiff Oncology's portfolio and strengthen its collaboration with Pfizer, positioning them competitively in the oncology market.

Published: June 18, 2026
Updated: June 18, 2026
Author: Humanexa Intelligence
Therapeutic area: Oncology / Colorectal Cancer
Company: Pfizer
Asset: Cardiff
Indication: metastatic colorectal cancer
Trial SummaryCLN

Phase III

metastatic colorectal cancer

Status

Active

Sponsor

Pfizer

Signal Score

8.4

Signal assessment

Signal strength

high

Confidence level

high

Signalhigh
Confidencehigh

Strategic implication

The ongoing trial of onvansertib in combination with standard therapies for metastatic colorectal cancer could significantly impact treatment options for patients with specific mutations. Success in this trial may enhance Cardiff Oncology's portfolio and strengthen its collaboration with Pfizer, positioning them competitively in the oncology market.

Why it matters

The ongoing trial of onvansertib in combination with standard therapies for metastatic colorectal cancer could significantly impact treatment options for patients with specific mutations. Success in this trial may enhance Cardiff Oncology's portfolio and strengthen its collaboration with Pfizer, positioning them competitively in the oncology market.

What changed

Trial Update

Analysis

A clinical trial is underway to evaluate onvansertib combined with standard therapies for first-line treatment of KRAS/NRAS-mutated metastatic colorectal cancer.

The ongoing trial of onvansertib in combination with standard therapies for metastatic colorectal cancer could significantly impact treatment options for patients with specific mutations. Success in this trial may enhance Cardiff Oncology's portfolio and strengthen its collaboration with Pfizer, positioning them competitively in the oncology market.

Monitor trial results for efficacy and safety, particularly the selection of the optimal dosing regimen.

Related companies & assets

Companies

  • Pfizer →

Assets

  • Cardiff →
  • Cardiff Oncology →

Sources & Humanexa intelligence

Source links

  • Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Ca ↗
  • Cardiff Oncology and Pfizer assess onvansertib in metastatic colorectal cancer trial ↗

Related Humanexa pages

  • Cardiff Oncology and Pfizer assess onvansertib in metastatic colorectal cancer trial →

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